Interests

• Gene Therapy

• Biomedical Engineering

• Drug Delivery
  

Thaddeus Gugu

Ph.D. Candidate

Gugu is currently enrolled as a Ph.D. student at the University of Waterloo School of Pharmacy. He previously completed a Ph.D. in 2021 at the University of Nigeria Nsukka where he studied targeted drug delivery and formulations, funded by the German In-Country/In-Region DAAD Scholarship. Gugu has also attended a 15 month research visit at the Drug Delivery System Excellence Center (DDSEC), Faculty of Pharmaceutical Sciences, Prince of Songkhla University, Thailand, where he worked on aerosolized drug delivery against Gram-negative bacterial resistance. His current project involves the development of a Lambda (λ) phage-based vaccine platform.

Education

• B.Pharm. University of Nigeria Nsukka (2014)

• M.Pharm. University of Nigeria Nsukka (2016)

• Ph.D. University of Nigeria Nsukka, 2021

Contact

• thgugu@uwaterloo.ca

• thaddeus.gugu@theraphage.bio

PUBLICATIONS:

• Kenechukwu, F. C., Ugwu, K. C., Offorbuike, C. S., Enyi, M. O., Gugu, T. H., et al. (2025). Solidified reverse micellar solution-based chitosan-coated solid lipid nanoparticles as a new approach to enhance oral delivery of artemether in malaria treatment. BMC Chemistry, 19, 64.

• Kenechukwu, F. C., Ezegwui, M. I., Gugu, T. H., et al. (2025). Engineering solidified reverse micellar solution-based chitosan-coated lipid nanoparticles for enhanced antimalarial activity of clotrimazole. BioNanoSci, 15, 236.

• Gugu, T. H., Uronnachi, E. M., Thawithong, E., & Srichana, T. (2024). Spray dried polymyxin B liposome for inhalation against gram-negative bacteria. Pharmaceutical Development and Technology, 29(10), 1133–1147.

• Uronnachi, E., Nakpheng, T., Gugu, T., & Srichana, T. (2024). Formulation and antimycotic evaluation of colloidal itraconazole-loaded metered dose sprays for treating superficial mycoses. AAPS PharmSciTech, 25, 156.

• Gugu, T. H., Agu, G. C., Uronnachi, E. M., & Chime, S. A. (2023). Enhanced anti-inflammatory and ulcerogenicity of Ibuprofen microsphere formulations using Irvingia wombolu fat (IRW) and moringa oil (MO) as co-lipids. BMC Complementary Medicine and Therapies, 23(1), 249.

• Uronnachi, E. M., Attama, A., Kenechukwu, F., Umeyor, C., Gugu, T., Nwakile, C., et al. (2022). Solidified reverse micellar solution-(SRMS-) based microparticles for enhanced oral bioavailability and systemic antifungal efficacy of miconazole nitrate in immunocompromised mice. BioMed Research International.

• Ezeibe, E. N., Onuigbo, E. B., Ugwu, C. N., Berebon, D. P., Gugu, T. H., Nwagwu, C. S., et al. (2022). Fluoroquinolones resistance and plasmid profile patterns of typhoidal Salmonella serovars isolated from human faecal samples in tertiary hospitals in South-East, Nigeria. Tropical Journal of Natural Product Research, 6(1), 138-143.

• Ujam, N. T., Adonu, C. C., Gugu, T. H., Onwusoba, R., Ike, C., Offiah, R. O., Chigbo, M. C., Okoye, F. B. C., & Esimone, C. O. (2022). Assessment of antiplasmodial and immunomodulatory activities of endophytic fungal metabolites from Azadirachta indica A. Juss. African Journal of Microbiology Research, 16(3), 121-131.

• Gugu, T. H., Onwusoba, R. C., Onyi, P. N., & Ozioko, A. C. (2020). Synergistic interaction of natural snail mucin and lincomycin for immuno-chemotherapy against streptopneumococcal infection: Checkerboard evaluations. International Journal of Pharmaceutical Investigation, 10(3), 379-383.

• Eze, C. O., Gugu, T. H., Evurani, S. A., Agbo, C. P., Okorie, J. E., & Oraeluno, J. N. (2020). Study of the antibody stimulation potentials of lactobacillus spp isolated from palm wine. African Journal of Biotechnology, 19(8), 576-583.

• Oli, A. N., Eze, D. E., Gugu, T. H., Ezeobi, I., Maduagwu, U. N., & Ihekwereme, C. P. (2017). Multi-antibiotic resistant extended-spectrum beta-lactamase producing bacteria pose a challenge to the effective treatment of wound and skin infections. Pan African Medical Journal, 27, 66.

• Umeyor, C. E., Kenechukwu, F. C., Attama, A. A., Gugu, T., & Ugochukwu, J. (2017). Surface modified self-nanoemulsifying formulations (SNFEs) for oral delivery of gentamicin: In vivo toxicological and pre-clinical chemistry evaluations. Current Nanomedicine, 7, 237-251.

• Ike, B., Ugwu, M. C., Ikegbunam, M. N., Nwobodo, D., Ejikeugwu, C., Gugu, T., & Esimone, C. O. (2016). Prevalence, antibiogram and molecular characterization of community-acquired methicillin-resistant Staphylococcus Aureus in AWKA, Anambra Nigeria. Open Microbiology Journal, 10, 211-221.

• Gugu, T. H., Chime, S. A., & Attama, A. A. (2015). Solid lipid microparticles: An approach for improving oral bioavailability of aspirin. Asian Journal of Pharmaceutical Sciences, 10(2), 425–432.

Presentations:

• Gugu et al, Spray-dried approach for inhaled polymyxin B liposome formulation against Gram-negative bacteria. Oral presentation at: 2nd International conference on veterinary and biomedical Sciences. University of Nigeria. 2024, April 17-19th, Enugu, Nigeria.

• Gugu et al, Enhanced Anti-inflammatory and Ulcerogenicity of Ibuprofen Microsphere formulations using Irvingia Wombolu Fat (IRW) and Moringer Oil (MO) as Co-lipids. Oral presentation at: 8th European Congress. 2023, October 12-13. London, UK

• Gugu et al, Biological Evaluations of Extract and Fractions of Combretum dolichopetalum leaf for the management of some tropical diseases (TDS). Oral presentation at: Joint International and Tropical Medicine Meeting. 2022, December 7-8. Bangkok, Thailand.

• Gugu et al, Artificial and phenotypic engineering of Serratia marcescens for the production of prodigiosin compound: Antimicrobial and anti-breast cancer evaluations. Oral presentation at: The 13th IMT-GT Uninet Biosciences International Conference. 2022, December 8-9. Bangkok, Thailand.

• Gugu et al, Optimized development, characterization and antimicrobial evaluation of bioactive prodigiosin potentials from Cephalosporin resistant Serratia marcescens. Oral presentation at: the 2nd Scientific Conference and Workshop. 2021, June 9-11. Enugu, Nigeria

• Gugu et al, Preliminary investigation of anti-inflammatory and infectious wound healing properties of shea butter marketed locally within Nsukka zone, Nigeria. Oral presentation at: SNJBS PharmaCon-2021; An international conference. 2021, December 3-6. Chandwad, Maharashtra.

• Gugu et al, Production of Prodigiosin from Serratia marcescens and Development of its Parenteral Nanoparticles Targeted against Triple-Negative Breast Cancer. Oral presentation at: The 1st International Conference on biologics research and development. 2021, July 1-4. Enugu, Nigeria

• Gugu et al,  Activity pattern of cephalosporins and plasmid profile of the potential resistant DNA of uropathogenic Staphylococcus aureus from in-patient subjects within Nsukka Urban. Oral presentation at: 18th Nigeria Association of Pharmacists in Academia (NAPA) Conference. 2020, August 24-26. Enugu, Nigeria.

Awards:

• Reinvent University Grant Award, (DDSEC), Prince of Songkla University, Thailand, 2022-2023

• DAAD In-country/In-Regional Scholarship, University of Nigeria Nsukka 2017- 2021

• UNN Needs Assessment TET-Fund award, 2020

• World Bank Partnership Project Grant; Center of Excellence, Africa University of Science and Technology, 2015-2017